Issue Date: May 28, 2007
Dendrimer Cleaves Cooperatively
The functional units of enzymes often cooperate with each other to carry out catalytic tasks efficiently. Chemists in Italy now show that metal complexes dotting the periphery of a dendrimer also can work cooperatively. Paolo Scrimin of the University of Padova and colleagues functionalized a dendrimer with Zn2+-bound triazacyclononane ligands. They found that it cleaves a phosphate diester model of RNA cooperatively, exhibiting a 270-fold rate acceleration compared with the Zn2+-triazacyclononane complex alone and . . .
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