Issue Date: June 4, 2007
Method identifies histone modifications
Post-translational modifications (PTMs) of histones—the protein spools that DNA is wound around—help regulate gene expression. Figuring out whether combinations of these PTMs make up a histone code has been difficult because of the challenge of determining multiple PTMs simultaneously. The H3 histone has such a complicated PTM pattern that analyzing intact proteins via high-resolution mass spectrometry (MS) has been insufficient for characterization. Craig A. Mizzen, Neil L. Kelleher, and coworkers at the University of . . .
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