Method identifies histone modifications | Chemical & Engineering News
 
 
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Volume 85 Issue 23 | p. 32 | Concentrates
Issue Date: June 4, 2007

Method identifies histone modifications

Department: Science & Technology
News Channels: JACS In C&EN

Post-translational modifications (PTMs) of histones—the protein spools that DNA is wound around—help regulate gene expression. Figuring out whether combinations of these PTMs make up a histone code has been difficult because of the challenge of determining multiple PTMs simultaneously. The H3 histone has such a complicated PTM pattern that analyzing intact proteins via high-resolution mass spectrometry (MS) has been insufficient for characterization. Craig A. Mizzen, Neil L. Kelleher, and coworkers at the University of . . .

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