Issue Date: July 23, 2007
Small Molecules Disrupt RNA Splicing
The identification of the first small molecules capable of disrupting the work of the spliceosome promises new insight into how this crucial biological machine helps convert DNA into proteins (Nat. Chem. Biol., DOI: 10.1038/nchembio.2007.16 and 10.1038/nchembio.2007.18). Before raw RNA transcripts of protein-coding genes can be converted into protein, the spliceosome must remove any unwanted and intervening RNA segments. Failure to splice out such intervening sequences, commonly called introns, before translation gives rise to flawed and . . .
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