Issue Date: April 21, 2008
Peptide Nanostructure Kills Cancer Cells
By adding crown ether moieties to a polypeptide, chemists in Canada have created a nanoscale chemotherapeutic compound that can selectively and efficiently kill prostate cancer cells (Chem. Commun., DOI: 10.1039/b800528a). The compound, designed by chemistry professor Normand Voyer and graduate students Pierre-Luc Boudreault, Mathieu Arseneault, and François Otis of Laval University, is based on a 14-residue helical peptide that contains four crown ethers (shown). Voyer's group previously showed that this 14-mer possesses . . .
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