Issue Date: July 7, 2008
Organic Fluorophore Switches On Demand
High-resolution, single-molecule imaging methods such as PALM and STORM require fluorophores that can be switched on and off on demand. Those methods often rely on fluorescent proteins that photobleach quickly and don't produce as many photons as small-molecule organic fluorophores. A team of chemists led by Stanford University's W. E. Moerner and Kent State University's Robert J. Twieg, report a new photoactivatable small organic fluorophore that's suitable for live-cell imaging (J. Am. Chem. Soc., DOI: . . .
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