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Volume 86 Issue 44 | p. 22 | Concentrates
Issue Date: November 3, 2008

Dendrimers Show Antibiotic Activity

Department: Science & Technology
News Channels: JACS In C&EN

A new class of dendrimers has promising antibiotic activity, killing prokaryotic bacteria cells while remaining largely nontoxic to eukaryotic human cells (J. Am. Chem. Soc., DOI: 10.1021/ja806912a). Chemistry and biomedical engineering professor Mark W. Grinstaff, postdoc Steven R. Meyers, and colleagues at Boston University synthesized two anionic amphiphilic dendrimers, based in part on past evidence that dendrimers with anionic charges are relatively nontoxic to animals. . . .

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