Issue Date: April 6, 2009
Orchestrating Genetic Expression
Without changing a single genetic letter in a multi-billion-letter genome, chemical modifications of chromatin, the macromolecular stage inside a cell's nucleus that bears DNA and that constitutes chromosomes, play genes like notes in a life-long score. For the most part, that score is inherited at conception, but it also can be edited in two primary ways during gestation, early childhood, and perhaps throughout life, and can even be passed down to the next generation.
One . . .
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