Volume 87 Issue 22 | p. 5 | News of The Week
Issue Date: June 1, 2009

Disorderly Proteins Turn Predictable

Spectroscopic evidence suggests a general strategy for finding inhibitors of unstructured proteins
Department: Science & Technology
News Channels: Analytical SCENE
Keywords: Biochemistry, protein c-Myc

Small-molecule-binding sites aren't just the hallmark of enzymes and receptors anymore. Chemists have found evidence that floppy, unstructured proteins contain regions prone to binding small molecules. The finding could lead to better tools for basic research on disordered proteins and may someday help researchers targeting such proteins in drug discovery.

Intrinsically disordered proteins play roles in gene transcription, cell division, and more, but researchers don't have a straightforward way of making molecules that alter their . . .

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