Issue Date: June 8, 2009
Keeping Body Time By Metabolomics
With a well-tuned mechanism rivaling that of the finest Swiss timepiece, the human body clock regulates changes in gene expression that lead to temporal oscillations of hormone and metabolite levels. As a result, people's internal "body time" can influence the efficacy and side effects of therapeutic drugs they are taking. But developing individualized "chronotherapy" to optimize the benefits of medicines has been hindered so far by a lack of clinical methods to measure body time. . . .
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