Volume 87 Issue 23 | p. 51 | Concentrates
Issue Date: June 8, 2009

Keeping Body Time By Metabolomics

By 24-hour monitoring of oscillating hormone and metabolite levels, scientists glean information on how to optimize the benefits of medicines
Department: Science & Technology
Keywords: therapeutic drugs, metabolite

With a well-tuned mechanism rivaling that of the finest Swiss timepiece, the human body clock regulates changes in gene expression that lead to temporal oscillations of hormone and metabolite levels. As a result, people's internal "body time" can influence the efficacy and side effects of therapeutic drugs they are taking. But developing individualized "chronotherapy" to optimize the benefits of medicines has been hindered so far by a lack of clinical methods to measure body time. . . .

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