Issue Date: August 10, 2009
DNA Bar Codes For Libraries
A research team led by Barry A. Morgan of GlaxoSmithKline has synthesized and screened a DNA-encoded library of 800 million small molecules to identify enzyme inhibitors (Nat. Chem. Biol., DOI: 10.1038/nchembio.211). Not only does the new method offer an unusually large library size for small-molecule screening, but it's also fast and relatively inexpensive, requiring less than 1 mg of target protein. Each small molecule, which consists of four chemically diverse building blocks, is . . .
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