Issue Date: September 14, 2009
Dopamine Triggers Drug-Abuse Memories
Experiments with mice are providing new details about how dopamine signaling in the brain sparks memories that reinforce the allure of addictive drugs (Neuron 2009, 63, 673). John A. Dani and Jianrong Tang of Baylor College of Medicine injected mice with nicotine, the addictive component of tobacco. The researchers showed that multiple doses of nicotine increase long-term potentiation at synapses in the hippocampus, a process that underlies memory formation and learning. They further . . .
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