Issue Date: October 5, 2009
Microgel Enzyme Inhibitor
A polymer formed around an enzyme—a construction known as a molecularly imprinted polymer (MIP)—can selectively inhibit the enzyme much better than a related small-molecule inhibitor, indicating that MIPs could be useful for drug development (J. Am. Chem. Soc., DOI: 10.1021/ja901600e). Scientists have had aspirations of using MIPs for analytical chemistry and biochemical applications, but the biological activity of the molded macromolecules has remained unprobed. A group led . . .
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