Issue Date: October 19, 2009
Trimming Sugars Yields Better Flu Antibodies
Truncating the sugar chains attached to an influenza protein leads to antibodies that can better bind to and neutralize the virus, reports a group led by Che Ma and Chi-Huey Wong at Academia Sinica, in Taiwan (Proc. Nat. Acad. Sci. USA, DOI: 10.1073/pnas.0909696106). The team investigated the glycosylation of influenza hemagglutinin (HA), a glycoprotein on the viral coat that enables the virus to enter respiratory-tract cells by binding to glycan receptors. The team . . .
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