Issue Date: May 10, 2010
Manipulating Stem Cells Through Their Metabolites
Stem cell differentiation—the process of turning a blank stem cell into a specific type of cell—can be regulated by controlling the reduction of stem cell metabolites, chemists at Scripps Research Institute have found (Nat. Chem. Biol., DOI: 10.1038/nchembio.364). Stem cells contain a pool of unsaturated molecules that decrease as stem cells mature. Oscar Yanes, Sheng Ding, and Gary Siuzdak discovered that they can inhibit differentiation by blocking certain enzymes that reduce . . .
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