Issue Date: May 31, 2010
Single-Molecule Assay Detects Cancer
A Massachusetts company has developed an assay that is 1,700 times more sensitive for detecting a cancer biomarker than existing tests (Nat. Biotechnol., DOI: 10.1038/nbt.1641). The technology, which Cambridge-based Quanterix calls SiMoA (single-molecule array), uses femtoliter-sized chambers to individually isolate antibody-coated microbeads that trap single biomarker molecules. Labeling the biomarker with an enzyme permits its detection by fluorescence microscopy. Quanterix researchers led by David C. Duffy in collaboration with Tufts University’s . . .
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