Issue Date: June 7, 2010
Enzyme’s Metal Cluster Is Nailed
A long-standing disagreement over the structure of a key metalloenzyme is over, thanks to efforts by several groups. The enzyme, called IspH, is found in pathogenic microorganisms but not in humans, making it a promising drug target, because medications aimed at it would kill the microorganisms without adversely affecting the people infected by them.
IspH has been an active focus of research by several groups for almost a decade. But difficulties in studying its iron-sulfur . . .
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