Issue Date: June 28, 2010
Versatile Catalyst Delivers CF3 Groups
Tack one more reaction onto the list that bulky ligands from MIT help accomplish—adding trifluoromethyl groups to aromatic rings. Trifluoromethyls make molecules more lipophilic and metabolically stable, among other desirable properties, so chemists in the drug and agrochemical industries are constantly trying to prepare them more efficiently. Stephen L. Buchwald and colleagues at MIT previously used a bulky, phosphine-containing ligand to install fluorine atoms on aromatic rings (C&EN, Aug. 17, 2009, . . .
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