Volume 88 Issue 27 | pp. 29-30
Issue Date: July 5, 2010

Amyloid’s Functions Expand

Molecule that is linked to alzheimer’s might do more than just cause disease
Department: Science & Technology
Keywords: Alzheimer's disease, amyloid-β, secretase, peptide, amyloid precursor protein

“Amyloid-β” has become a four-letter word for some researchers of Alzheimer’s disease.

The pesky peptide has long been seen as a possible cause of Alz­heimer’s. It clumps into aggregates that could trigger the disease by mucking up brain tissue and interfering with normal neurological processes.

Evidence is mounting, however, that amyloid-β plays non-disease-causing roles in the brain. “Have we established that to be so?” asks Robert D. Moir, an Alzheimer’s researcher at Massachusetts . . .

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