Issue Date: July 19, 2010
Mimic Aids Study Of Protein Acetylation
Like protein phosphorylation, acetylation of lysine residues on proteins may have an important regulatory role in cell pathways. Thousands of mammalian proteins are naturally acetylated, but it’s technically difficult to acetylate lysine groups in the lab, complicating the study of the functional consequences of acetylation. Philip A. Cole of Johns Hopkins University School of Medicine and coworkers have now developed an easier method: derivatizing cysteines with methylthiocarbonyl-aziridine (MTCA) to create a thiocarbamate mimic . . .
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