Issue Date: July 19, 2010
How Valproate Affects Bones
A proteomic study suggests how the epilepsy and bipolar disorder drug sodium valproate leads to bone loss: It reduces production of collagen and osteonectin, both critical proteins for bones (J. Proteome Res., DOI: 10.1021/pr1005263). Valproate has been in use for more than 40 years, mostly as an anticonvulsant or mood stabilizer. But the reason for its bone . . .
To view the rest of this content, please log in with your ACS ID.
- Chemical & Engineering News
- ISSN 0009-2347
- Copyright © American Chemical Society