Attacking Amyloids | January 25, 2010 Issue - Vol. 88 Issue 4 | Chemical & Engineering News
Volume 88 Issue 4 | pp. 30-32
Issue Date: January 25, 2010

Attacking Amyloids

Efforts to deter protein misfolding yield promising drug candidates for degenerative diseases
Department: Science & Technology
Keywords: amyloid, Alzheimer's, protein misfolding, tafamidis

People live longer these days, and with increasing age an unwelcome visitor often tags along: a greater tendency to develop degenerative diseases. A new drug discovery strategy—minimizing amyloid deposition—is now being pursued to help fight these debilitating conditions.

In degenerative diseases like Alzheimer's, insoluble amyloid deposits form from proteins gone awry in the brain or other organs. The misbehaving proteins misfold and aggregate to form fibrous amyloid deposits.

Some drugs are available to manage symptoms . . .

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