Issue Date: October 11, 2010
Ubiquitins Are Finally United
Chains of ubiquitin proteins play key roles in cellular chemistry, including directing unwanted proteins to the proteasome for disposal. That function is carried out by a type of ubiquitin chain called K48. Another type, K11, marks proteins for turnover in the cell cycle, and one called K63 has a variety of functions such as activating protein kinases.
But in addition to these three types of homogeneous ubiquitin chains—so called because each is linked internally in . . .
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