Prion Aggregate Size Affects Transmissibility | November 1, 2010 Issue - Vol. 88 Issue 44 | Chemical & Engineering News
 
 
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Volume 88 Issue 44 | p. 25 | Concentrates
Issue Date: November 1, 2010

Prion Aggregate Size Affects Transmissibility

The size of prion aggregates affects their ability to induce further aggregation and cause protein-misfolding diseases
Department: Science & Technology
Keywords: prion, aggregation, Alzheimer?s, mad cow

In work that could aid understanding of protein-misfolding diseases, researchers have found that the size of prion aggregates affects their ability to induce further aggregation and cause illness (Science 2010, 330, 680). The prion hypothesis proposes that aggregates of misfolded infectious prion protein cause conditions such as mad cow disease in cattle and Creutzfeldt-Jakob disease in people by acting as seeds for the transformation of normally folded prion protein into more of the misfolded infectious . . .

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