Study Strengthens Alzheimer's Link To Cholesterol | February 8, 2010 Issue - Vol. 88 Issue 6 | Chemical & Engineering News
 
 
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Volume 88 Issue 6 | pp. 48-49 | Concentrates
Issue Date: February 8, 2010

Study Strengthens Alzheimer's Link To Cholesterol

Findings on the mechanism of a cholesterol metabolism pathway could aid development of new therapeutics
Department: Science & Technology
Keywords: Alzheimer?s disease, cholesterol, metabolism

Findings on the molecular mechanism of a cholesterol metabolism pathway could aid development of a new class of Alzheimer’s disease therapeutics, according to a research report. Cholesterol metabolism is known to play a role in the accumulation of amyloid β, a peptide associated with Alzheimer’s. Dora M. Kovacs of Harvard Medical School and coworkers previously showed that inhibitors of acyl-coenzyme A:cholesterol acyltransferase (ACAT) reduce amyloid β accumulation in cell and animal tests, but the way . . .

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