Issue Date: February 8, 2010
Study Strengthens Alzheimer's Link To Cholesterol
Findings on the molecular mechanism of a cholesterol metabolism pathway could aid development of a new class of Alzheimer’s disease therapeutics, according to a research report. Cholesterol metabolism is known to play a role in the accumulation of amyloid β, a peptide associated with Alzheimer’s. Dora M. Kovacs of Harvard Medical School and coworkers previously showed that inhibitors of acyl-coenzyme A:cholesterol acyltransferase (ACAT) reduce amyloid β accumulation in cell and animal tests, but the way . . .
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