Volume 89 Issue 23 | p. 38 | Concentrates
Issue Date: June 6, 2011

Biomarker Associations Often Overestimated

Most reported biomarkers proposed to diagnose disease or monitor treatment don’t live up to their initial billing
Department: Science & Technology
News Channels: Analytical SCENE
Keywords: biomarkers, meta-analysis, risk analysis

Most biomarkers reported as potential determinants of disease risk, disease progression, or response to treatment don’t live up to their billing as originally reported, according to a statistical analysis (J. Am. Med. Assoc., DOI: 10.1001/jama.2011.713). John P. A. Ioannidis of Stanford University School of Medicine and Orestis A. Panagiotou of the University of Ioannina School of Medicine, in Greece, examined 35 highly cited biomarker associations to find out whether the reported . . .

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