Issue Date: June 27, 2011
Herpes-related octasaccharides inhibit infection
Herpes simplex virus, which causes skin and mucous-membrane lesions, infects cells by interacting with heparan sulfate found on cell surfaces. Researchers in Taiwan have now synthesized octasaccharides resembling those glycans, and the oligomers turn out to inhibit viral infection by competing with cell-surface virus-glycan interactions. The work was carried out by Shang-Cheng Hung and coworkers at Academia Sinica (Nat. Chem.,DOI: 10.1038/nchem.1073). It is known that attachment of herpesvirus to cell-surface heparan sulfate proteoglycans enables . . .
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