Issue Date: July 11, 2011
Raman Senses Sugars On Proteins
Chemists in England have demonstrated for the first time that Raman spectroscopy can differentiate between the native and glycosylated forms of a protein (Anal. Chem., DOI: 10.1021/ac2012009). When pharmaceutical companies produce protein-based drugs, such as therapeutic antibodies, they must ensure the proteins have the proper sugar groups attached. The wrong sugars may decrease a protein’s effectiveness or even cause a harmful immune reaction, says
You Do Not Have Access to C&EN Protected Content.