Volume 89 Issue 28 | p. 32 | Concentrates
Issue Date: July 11, 2011

Raman Senses Sugars On Proteins

Department: Science & Technology
Keywords: glycosylation, glycoprotein, Raman spectroscopy

Chemists in England have demonstrated for the first time that Raman spectroscopy can differentiate between the native and glycosylated forms of a protein (Anal. Chem., DOI: 10.1021/ac2012009). When pharmaceutical companies produce protein-based drugs, such as therapeutic antibodies, they must ensure the proteins have the proper sugar groups attached. The wrong sugars may decrease a protein’s effectiveness or even cause a harmful immune reaction, says . . .

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