Issue Date: September 5, 2011
Covalent Drugs Form Long-Lived Ties
When most small-molecule drugs meet a protein target, they nestle close to their intended. But the flirtatious relationship between drug and target is often fleeting, with the drug repeatedly drifting away and coming back. Like a teenager with no interest in settling down, the drug forms no permanent bond with its target.
Some small molecules, however, do forge lasting ties. Their irreversible covalent bonds with proteins link compound and protein for good.
The pharmaceutical industry . . .
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