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Volume 89 Issue 42 | p. 11 | News of The Week
Issue Date: October 17, 2011

Identifying Modified Cells

Molecular Biology: Technique tags and enriches cells genetically altered by nucleases
Department: Science & Technology
Keywords: zinc finger nuclease , TAL effector nuclease, fluorescence, genetic engineering, gene knockouts

A new technique identifies and enriches cells whose genomes have been modified by custom-designed nucleases. The method could promote the use of nucleases to tweak genomes for various applications—for example, to study the roles of specific genes and to develop gene therapies.

Zinc finger nucleases and transcription-activator-like effector nucleases customized to target specific genes are available commercially and can also be designed by researchers in their laboratories. They bind and cleave specific gene sequences in . . .

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ISSN 0009-2347
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