Volume 89 Issue 50 | p. 26 | Concentrates
Issue Date: December 12, 2011

Catalyst Promotes Acyl Transfer Three Ways

Palladacycle enhances reaction kinetics by a factor of 100 million
Department: Science & Technology
News Channels: JACS In C&EN, Materials SCENE
Keywords: methanolysis, palladacycle, thioamide

Computation and experiment have been used to design a catalytic process with a three-part mechanism that makes a metal-promoted acyl transfer reaction occur 108 times faster than the uncatalyzed reaction. Nicholas J. Mosey, R. Stan Brown, and coworkers at Queen’s University, in Kingston, Ontario, developed the unusual catalyst, a palladacycle, to promote the methanolysis of a thioamide (J. Am. Chem. Soc., DOI: . . .

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