Issue Date: December 19, 2011
Genomics: RNAi Adapted For Mammals
In 2001, the then-nascent field of RNA interference took a leap forward when scientists showed that the gene-silencing method worked in human cells, not just in lower organisms.
In RNAi, short pieces of double-stranded RNA guide complementary strands of messenger RNA to a protein complex known as RISC, the RNA-induced silencing complex. RISC cleaves the mRNA, preventing its translation into protein.
In earlier work, scientists had shown that gene-length strands of RNA shut down all . . .
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