Issue Date: February 14, 2011
Neurotoxic Oligomer’s Structure Uncovered
Using small-angle X-ray scattering (SAXS), an international research team has determined the low-resolution structure of α-synuclein oligomer, an aggregated protein intermediate thought to be part of the fibril formation process that is a hallmark of Parkinson’s disease (Proc. Natl. Acad. Sci. USA, DOI: 10.1073/pnas.1013225108). Scientists have suggested that oligomers, rather than protein monomers or fibrils, are the toxic species involved in the neurodegenerative disorder. But questions about the role of oligomers in fibril . . .
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