Web Date: July 15, 2011
Solving The Mystery Of Sugar Chain Growth
Mycobacterium tuberculosis, the microbe responsible for tuberculosis, uses an unusually strong cell wall, fortified with a carbohydrate called galactan, to protect itself from harsh environments and its host’s immune system. Sugar polymers like galactan are built by enzymes called glycosyltransferases, which add successive sugar molecules to a chain, like beads on a string. Now researchers have developed an assay based on mass spectrometry to answer a long-standing question about the mechanism of these enzymes (J. . . .
You Do Not Have Access to C&EN Protected Content.
- Chemical & Engineering News
- ISSN 0009-2347
- Copyright © American Chemical Society