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Web Date: September 26, 2011

Cheap, Simple Test Spots Protein-Protein Interactions

Biological Assay: Using graphene oxide, a new method could help researchers find peptide-based drugs
Department: ACS News
News Channels: Analytical SCENE
Keywords: peptide drugs, protein-protein interactions, graphene oxide, biological assay, fluorescence spectroscopy

A graphene oxide-based assay could provide chemists with an inexpensive means to detect protein-protein interactions (Anal. Chem., DOI: 10.1021/ac200617k).

To discover peptide-based drug candidates, researchers often monitor how a disease-related protein interacts with libraries of small peptides. The biggest challenge is developing an easily measurable signal for when the proteins bind to peptides, says Chun-Hua Lu of Fuzhou University, in China. Fluorescence resonance energy transfer (FRET) spectroscopy, which monitors the distance between fluorescent . . .

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