New Method Isolates Membrane Proteins | Chemical & Engineering News
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Web Date: October 10, 2011

New Method Isolates Membrane Proteins

Protein Purification: Technique separates proteins on a lipid bilayer
Department: Science & Technology
News Channels: Analytical SCENE, Biological SCENE
Keywords: protein separation, electrophoresis, capillary electrophoresis, membrane proteins

Chemists have a new way using lipid bilayers to separate insoluble membrane proteins (Anal. Chem., DOI: 10.1021/ac201768k). The technique could help scientists study the function of these often difficult-to-handle proteins, including enabling research on pharmaceutically relevant properties such as how small molecules bind to them, the researchers say.

To get membrane proteins into solution for standard purification methods, chemists typically add detergents and sonicate the mixture. But this process can disrupt the proteins’ structures . . .

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