Issue Date: April 2, 2012
Histone Acetylation Allows DNA Unpacking
Acetylation of the tail of histone protein H4 is a key modification known to play a role in activating gene expression. Structural modeling studies by Garegin A. Papoian and Davit Potoyan of the University of Maryland now illuminate how the modification may work. To pack into chromosomes, DNA wraps around histone octamers, and the DNA-histone complexes further coil into fibers. Although histone tails are intrinsically disordered, Papoian and Potoyan still find that . . .
You Do Not Have Access to C&EN Protected Content.
- Chemical & Engineering News
- ISSN 0009-2347
- Copyright © American Chemical Society