Histone Acetylation Allows DNA Unpacking | Chemical & Engineering News
Volume 90 Issue 14 | p. 25 | Concentrates
Issue Date: April 2, 2012

Histone Acetylation Allows DNA Unpacking

ACS Meeting News: Modeling study hints at how the modification activates gene expression
Department: Science & Technology
News Channels: Biological SCENE
Keywords: histone, acetylation, posttranslational modification, epigenetics

Acetylation of the tail of histone protein H4 is a key modification known to play a role in activating gene expression. Structural modeling studies by Garegin A. Papoian and Davit Potoyan of the University of Maryland now illuminate how the modification may work. To pack into chromosomes, DNA wraps around histone octamers, and the DNA-histone complexes further coil into fibers. Although histone tails are intrinsically disordered, Papoian and Potoyan still find that . . .

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