Issue Date: May 7, 2012
Amyloid-β Gets Toxic Helping Hand
Amyloid-β, the peptide that misfolds and then forms plaques in the brains of Alzheimer’s patients, likely misfolds with help from a less prevalent, modified version of itself, according to a report in Nature (DOI: 10.1038/nature11060). Scientists have suspected that forms of amyloid-β modified with an amino-terminal pyroglutamate trigger unmodified amyloid to misfold, but they haven’t been sure of the mechanism for this interaction. On the basis . . .
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