Volume 90 Issue 19 | p. 8 | News of The Week
Issue Date: May 7, 2012

Bespoke Enzymes Push The Envelope

Protein Design: Highly efficient, long-lived mimics may help reveal how natural oxidases work
Department: Science & Technology
News Channels: Biological SCENE
Keywords: protein design, enzymes, oxygen reduction, reactive oxygen species, ROS

Designed metalloenzymes made by modifying a native protein scaffold have shown unusually high levels of efficiency and longevity and have revealed new details about the way oxidases, the natural enzymes they mimic, may work. The study is an important step in efforts to design customized enzymes for a variety of potential biological and alternative-energy applications.

Most designed enzymes have relatively simple active-site structures, low activity, and limited turnovers (duration of activity). Designing artificial enzymes with . . .

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