Volume 90 Issue 2 | p. 9 | News of The Week
Issue Date: January 9, 2012

Choose Your Own Analytical Range

Biosensors: Mixtures of receptors with different affinities enable expansion of dynamic range
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE, Analytical SCENE
Keywords: biosensors, molecular beacons, dynamic range

By combining sets of DNA receptors with different binding affinities, a research team has created biosensors that detect specific DNA sequences over customized concentration ranges (J. Am. Chem. Soc., DOI: 10.1021/ja209850j). The approach extends concentration range without impairing specificity, a trade-off that has plagued past biosensor range-improvement efforts.

Kevin W. Plaxco, a chemistry professor at the University of California, Santa Barbara, whose group carried out the study, notes that conventional single-site DNA receptors . . .

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