Solvent Viscosity Tunes DNA Folding | Chemical & Engineering News
 
 
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Volume 90 Issue 24 | p. 37 | Concentrates
Issue Date: June 11, 2012

Solvent Viscosity Tunes DNA Folding

DNA completes folding into G-quadruplexes over months in a high-viscosity solvent, but over minutes in a low-viscosity one
Department: Science & Technology
News Channels: Biological SCENE, JACS In C&EN
Keywords: G-quadruplex, telomere, DNA, viscosity

In work with implications for future studies on DNA folding into structures called G-quadruplexes, Nicholas V. Hud and coworkers at Georgia Tech have found that solvent viscosity can tune the kinetics and pathway of G-quadruplex structural transitions (J. Am. Chem. Soc., DOI: 10.1021/ja303499m). Guanine-rich DNA sequences at chromosome ends, known as telomeres, can form . . .

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