New Way To Hit Alzheimer’s Target: Caspase-6 Inhibitor | June 18, 2012 Issue - Vol. 90 Issue 25 | Chemical & Engineering News
 
 
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Volume 90 Issue 25 | p. 7 | News of The Week
Issue Date: June 18, 2012

New Way To Hit Alzheimer’s Target: Caspase-6 Inhibitor

Drug Discovery: Agent with novel mechanism improves selectivity for caspase-6 enzyme
Department: Science & Technology
Keywords: Alzheimer’s, caspase, zymogen, inhibitor

An agent that inhibits the protease enzyme caspase-6 in a totally new way could help lead to a novel type of medication for Alzheimer’s disease, a condition in which caspase-6 may play a key role.

Drug researchers in academia and the pharmaceutical industry have been actively pursuing inhibitors of caspase-6 and other caspases as potential Alzheimer’s medications for several years. But inhibitors against caspases have been found to cause serious side effects, and none has . . .

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