Volume 90 Issue 26 | p. 10 | News of The Week
Issue Date: June 25, 2012

Anticancer Prospect Made From Scratch

Total Synthesis: Chemists map route to natural product (+)-fusarisetin A
Department: Science & Technology
News Channels: Biological SCENE, JACS In C&EN
Keywords: fusarisetin, total synthesis, cancer, metastasis

The natural product (+)-fusarisetin A, which has promising anticancer properties and an unusually complex structure, has succumbed to total synthesis.

(+)-Fusarisetin A has intrigued drug designers because experiments show that it inhibits migration and metastasis of cancer cells, seemingly without exhibiting cell-killing proclivities that might point to toxic tendencies. The compound’s complicated architecture, including a fused five-ring system and 10 stereocenters, has made it challenging to synthesize.

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