Issue Date: June 25, 2012
Anticancer Prospect Made From Scratch
The natural product (+)-fusarisetin A, which has promising anticancer properties and an unusually complex structure, has succumbed to total synthesis.
(+)-Fusarisetin A has intrigued drug designers because experiments show that it inhibits migration and metastasis of cancer cells, seemingly without exhibiting cell-killing proclivities that might point to toxic tendencies. The compound’s complicated architecture, including a fused five-ring system and 10 stereocenters, has made it challenging to synthesize.
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- Chemical & Engineering News
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