Single Amino Acid Forms Fibrils | June 25, 2012 Issue - Vol. 90 Issue 26 | Chemical & Engineering News
Volume 90 Issue 26 | p. 10 | News of The Week
Issue Date: June 25, 2012

Single Amino Acid Forms Fibrils

Amyloid Disease: Phenylalanine aggregates may have a role in phenylketonuria
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE
Keywords: amyloid, amino acids, phenylalanine, fibrils

The amino acid phenylalanine assembles into toxic fibrils, researchers at Tel Aviv University and the University of Zurich report (Nat. Chem. Biol., DOI: 10.1039/nchembio.1002). This is the first time that individual amino acid molecules have been shown to assemble into fibrils.

The findings suggest that the disease phenylketonuria, which is characterized by phenylalanine accumulation and may lead to severe problems with brain development, could . . .

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