Issue Date: July 2, 2012
Cut-And-Sew Route Makes Fused Rings
With help from a chelating ligand, chemists have found an efficient new route to fused-ring systems similar to those in alkaloid drugs such as morphine or codeine (Angew. Chem. Int. Ed., DOI: 10.1002/anie.201202771). The work also presents a new twist on carbon-carbon bond activation. Chemists typically forge alkaloid core structures with lengthy multistep syntheses. Now, assistant professor . . .
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