Zinc Finger Agents Enter Cells Solo | July 9, 2012 Issue - Vol. 90 Issue 28 | Chemical & Engineering News
 
 
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Volume 90 Issue 28 | p. 6 | News of The Week
Issue Date: July 9, 2012

Zinc Finger Agents Enter Cells Solo

Molecular Biology: The gene-modifying proteins can be delivered without viral packaging of their genes
Department: Science & Technology | Collection: Stem Cells, Life Sciences
News Channels: Biological SCENE
Keywords: zinc finger nuclease, gene therapy

A new method to bring the gene-modifying proteins called zinc finger nucleases (ZFNs) inside cells could make it possible to minimize the side effects of gene therapy.

In ZFN-based gene therapy, genes for ZFNs are packaged inside viral vectors to be introduced into cells. The cells then express the proteins, which modify target genes. Two vector-delivered ZFNs are currently in clinical trials—one of them modifies the gene for CCR5, a receptor HIV uses to infect . . .

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