Issue Date: July 9, 2012
Zinc Finger Agents Enter Cells Solo
A new method to bring the gene-modifying proteins called zinc finger nucleases (ZFNs) inside cells could make it possible to minimize the side effects of gene therapy.
In ZFN-based gene therapy, genes for ZFNs are packaged inside viral vectors to be introduced into cells. The cells then express the proteins, which modify target genes. Two vector-delivered ZFNs are currently in clinical trials—one of them modifies the gene for CCR5, a receptor HIV uses to infect . . .
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