Tau Protein, Synthetically | January 23, 2012 Issue - Vol. 90 Issue 4 | Chemical & Engineering News
Volume 90 Issue 4 | p. 6 | News of The Week
Issue Date: January 23, 2012

Tau Protein, Synthetically

Protein Engineering: Researchers make, modify key player in Alzheimer’s disease
Department: Science & Technology
News Channels: Biological SCENE
Keywords: tau protein, expressed protein ligation, native chemical ligation, peptide synthesis, protein engineering, tau phosphorylation, hyperphosphorylation

Researchers in Germany have developed a method for producing a synthetic version of tau protein labeled with phosphate at a specific site. Being able to make a full version of tau—one of the main actors in Alzheimer’s disease—and to chemically modify it at a specific amino acid site should help scientists uncover more about the mechanism by which tau’s malfunction leads to disease.

Normally, tau stabilizes microtubules, which act as scaffolding inside cells such as . . .

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