Volume 90 Issue 42 | p. 6 | News of The Week
Issue Date: October 15, 2012 | Web Date: October 12, 2012

Robert J. Lefkowitz And Brian K. Kobilka Win 2012 Nobel Prize In Chemistry

Duo shares honor for shedding light on signaling proteins
Department: Science & Technology
News Channels: Analytical SCENE, Biological SCENE
Keywords: biochemistry, Structural biology, GPCR, signal transduction, drug development

Robert J. Lefkowitz, 69, and Brian K. Kobilka, 57, will take home this year’s Nobel Prize in Chemistry for unraveling the molecular workings of G-protein-coupled receptors (GPCRs). The receptors are a family of proteins that transmit critical biological messages for functions such as vision, smell, taste, and neurotransmission, and they are targets for myriad drugs.

GPCRs “are crucially positioned to regulate almost every known physiological process in humans,” Lefkowitz, . . .

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