Volume 90 Issue 46 | p. 8 | News of The Week
Issue Date: November 12, 2012 | Web Date: November 19, 2012

Proteins Made To Order

Design Rules: Principles integrate structure and function from the ground up
Department: Science & Technology
News Channels: Biological SCENE
Keywords: proteins, protein design

Efforts to design novel protein catalysts have typically involved modifying naturally occurring proteins for a new purpose. But the resulting proteins are often less than ideal. Now, David Baker of the University of Washington, Seattle; Gaetano T. Montelione of Rutgers University, Piscataway; and coworkers have developed guidelines for designing proteins from the ground up with results that are close to ideal (Nature, DOI: . . .

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