Volume 90 Issue 52 | p. 9 | News of The Week
Issue Date: December 24, 2012

Whole-Genome Sequencing Of Single Cells

Molecular Biology: New DNA amplification method improves sequencing of single cells?
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE, Analytical SCENE
Keywords: DNA sequencing, genome, single cell

A tiny genetic change in a single cell could hold the seeds of an inherited disease or heightened cancer risk. But such changes are hard to find, because existing DNA amplification methods are poorly suited for single-cell genome sequencing—they are better at bulk sequences. However, a single cell is often all that’s available for applications such as prenatal screening or analysis of circulating tumor cells.

A new amplification method smooths out sequence biases that hamper . . .

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