Small Molecules Unmasked In Mass Spectrometry | Chemical & Engineering News
 
 
  • CORRECTION: This story was updated on Aug. 6, 2012, to eliminate using an incorrect word, "drug," to describe the natural product berberine.

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Web Date: July 30, 2012

Small Molecules Unmasked In Mass Spectrometry

Analysis: Deuterated matrix allows researchers to probe small-molecule pharmaceuticals with MALDI mass spec
Department: Science & Technology | Collection: Life Sciences
News Channels: Analytical SCENE, Biological SCENE
Keywords: MALDI, small molecules, pharmaceuticals, mass spectrometry

Mass spectrometry is useful for identifying many molecules, but one popular technique for probing biomolecules struggles to analyze small molecules. Now researchers have discovered that simply deuterating the matrix used in matrix-assisted laser desorption ionization (MALDI) mass spectrometry allows them to identify previously hidden small molecules, including neurotransmitters and pharmaceuticals (Anal. Chem., DOI: "; $("#ERA_RC").html(contextualDefault); } }); var era_rc1 = {StyleId: '1',ERADomain: 'cen.firstlightera.com'};

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